• 2019-10
  • 2019-11
  • 2020-03
  • 2020-07
  • 2020-08
  • br Abbreviation Full name br AGE Aged garlic extract


    Abbreviation Full name
    AGE Aged garlic extract
    SAMC S-allylmercaptocysteine
    ROS Reactive oxygen species
    ER Estrogen receptor
    PSA Prostate specific antigen
    PSMA Prostate specific membrane antigen
    ATC Anaplastic thyroid cancer
    [4] Aggarwal BB, Shishodia S. Suppression of the nuclear factor-kappaB activation pathway by spice-derived phytoche-micals: reasoning for seasoning [J]. Ann N Y Acad Sci, 2004,
    [5] Xiao DH, Pinto JT, Soh JW, et al. Induction of apoptosis by the garlic-derived Dynasore S-allylmercaptocysteine (SAMC) is associated with microtubule depolymerization and c-Jun NH2-terminal kinase 1 activation [J]. Cancer Res, 2003, 63(20): 6825-6837.
    [11] Sathibabu Uddandrao VV, Brahmanaidu P, Saravanan G. Therapeutical perspectives of S-allylcysteine: effect on diabetes and other disorders in animal models [J]. Cardiovasc Hematol Agents Med Chem, 2016, 15(2):71-77
    [12] Colin-Gonzalez AL, Santana RA, Silva-Islas CA, et al. The antioxidant mechanisms underlying the aged garlic extract- and S-allylcysteine-induced protection [J]. Oxid Med Cell Longev, 2012, 2012: 907162
    [13] Pedraza-Chaverri J, Barrera D, Maldonado PD, et al. S-allyl-mercaptocysteine scavenges hydroxyl radical and singlet oxygen in vitro and attenuates gentamicin-induced oxidative and nitro-sative stress and renal damage in vivo [J]. BMC Clin Pharmacol, 2004, 4: 5. [14] Chu TC, Han P, Han G, et al. Intraocular pressure lowering by S-allylmercaptocysteine in rabbits [J]. J Ocul Pharmacol Ther, 1999, 15(1): 9-17.
    [16] Sumioka I, Matsura T, Yamada K. Therapeutic effect of S-allylmercaptocysteine on acetaminophen-induced liver injury in mice [J]. Eur Dynasore J Pharmacol, 2001, 433(2-3): 177-185. [17] Xiao J, Liong EC, Ling MT, et al. S-allylmercaptocysteine reduces carbon tetrachloride-induced hepatic oxidative stress and necroinflammation via nuclear factor kappa B-dependent pathways in mice [J]. Eur J Nutr, 2012, 51(3): 323-333.
    [18] Xiao J, Ching YP, Liong EC, et al. Garlic-derived S-allyl-mercaptocysteine is a hepato-protective agent in non-alcoholic fatty liver disease in vivo animal model [J]. Eur J Nutr, 2013, 52(1): 179-191. [19] Xiao J, Guo R, Fung ML, et al. Garlic-derived S-allylmerca-ptocysteine ameliorates nonalcoholic fatty liver disease in a rat model through inhibition of apoptosis and enhancing auto-phagy [J]. Evid Based Complement Alternat Med, 2013, 2013: 642920.
    [20] Yang L, Yang M, Li S, et al. S-allylmercaptocysteine attenuates
    posaconazole-induced adverse effects in mice through antioxidation and anti-inflammation [J]. Int Immunopharmacol, 2018, 58:9-14.
    [21] Shirin H, Pinto JT, Kawabata Y, et al. Antiproliferative effects of S-allylmercaptocysteine on colon cancer cells when tested alone or in combination with sulindac sulfide [J]. Cancer Res, 2001, 61(2): 725-731.
    [23] Liang D, Qin Y, Zhao W, et al. S-allylmercaptocysteine effectively inhibits the proliferation of colorectal cancer cells under in vitro and in vivo conditions [J]. Cancer Lett, 2011, 310(1): 69-76. [24] Zhang Y, Li HY, Zhang ZH, et al. Garlic-derived compound S-allylmercaptocysteine inhibits cell growth and induces apoptosis via the JNK and p38 pathways in human colorectal carcinoma cells [J]. Oncol Lett, 2014, 8(6): 2591-2596.
    [25] Pinto JT, Qiao C, Xing J, et al. Effects of garlic thioallyl derivatives on growth, glutathione concentration, and polyamine formation of human prostate carcinoma cells in culture [J]. Am J Clin Nutr, 1997, 66(2): 398-405.
    [26] Sigounas G, Hooker J, Anagnostou A, et al. S-allylmer-captocysteine inhibits cell proliferation and reduces the viability of erythroleukemia, breast, and prostate cancer cell lines [J]. Nutr Cancer, 1997, 27(2): 186-191. [27] Pinto JT, Qiao C, Xing J, et al. Alterations of prostate biomarker expression and testosterone utilization in human LNCaP prostatic carcinoma cells by garlic-derived S-allylme-rcaptocysteine [J]. Prostate, 2000, 45(4): 304-314.
    [32] Yan JY, Tian FM, Hu WN, et al. Apoptosis of human gastric cancer cells line SGC 7901 induced by garlic-derived compound S-allylmercaptocysteine (SAMC) [J]. Eur Rev Med
    [39] Wang K, Wang Y, Qi Q, et al. Inhibitory effects of S-allyl-mercaptocysteine against benzo(a)pyrene-induced precancerous carcinogenesis in human lung cells [J]. Int Immunopharmacol, 2016, 34: 37-43.
    [41] Lea MA, Rasheed M, Randolph VM, et al. Induction of histone acetylation and inhibition of growth of mouse erythroleukemia cells by S-allylmercaptocysteine [J]. Nutr Cancer, 2002, 43(1): 90-102. [42] Zhu X, Jiang X, Li A, et al. S-allylmercaptocysteine suppresses the growth of human gastric cancer xenografts through induction of apoptosis and regulation of MAPK and PI3K/Akt signaling pathways [J]. Biochem Biophys Res Commun, 2017, 491(3): 821-826.