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br This is a PDF
2020-08-12
This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it beta-Nicotinamide mononucleot
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Resolvin E 1 br It may also be possible to repolarize TAMs u
2020-08-07
It may also be possible to repolarize TAMs using drug-free inorganic NPs. High levels of intracellular iron can modulate cytokine signaling and cell proliferation by increasing oxidative stress, particularly in the oxidative environment of the TME. Ferumoxytol is a superparamagnetic iron-oxide NP
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On the basis of the
2020-08-07
On the basis of the observed changes in the expression patterns of apoptosis-associated proteins, we speculated that BA-induced apoptosis may be via mitochondria‐mediated apoptotic pathway. To verify the hypothesis, we detected the alterations in the mitochondrial membrane potential by FCM using a m
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br Combined genotypes were evaluated as genotypes combinatio
2020-08-06
Combined genotypes were evaluated as genotypes combination of these two polymorphisms. A total of 9 combinations were studied and as shown in Table 3, the combination of Arg/Arg in WRAP53 and Arg/ Arg in TP53 were the most frequent combination in both cases and controls. Pairwise haplotype esti
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br Corresponding author at Vanderbilt
2020-08-06
Corresponding author at: Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, MCN B-2104, 1161 21st Avenue South, Nashville, TN, 37232-2400, USA. E-mail address: [email protected] (Q. Cai). smoking status can modify this potential a
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Kainic acid br In addition there was no significant
2020-08-06
In addition, there was no significant difference in CRP levels among premenopausal and post-menopausal breast cancer patients (P > 0.05). Higher and moderate CRP levels associated signifi-cantly with death (P = 0.02) as well as metastasis and recurrence (P = 0.03). Therefore moderate and high CRP
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br Table br Univariate and
2020-08-04
Table 2 Univariate and multivariable logistic regression predictors of continent diversion. Statistically significant if bold Univariate Multivariable OR CI P OR CI P Age Male Ref − − Female zip code of residence Not insured Ref − − Private/Managed Care
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b iframe width height src https www youtube com
2020-08-02
r> Statistical analyses Data are represented as mean SD. Non-repeated ANOVA with post hoc Dunnett’s test was performed to determine the statistical significance compared to a corresponding negative control. Statistical significance was defined as p Results Nor-wogonin has superior antiproli
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br were going to be used
2020-07-31
were going to be used throughout our study. The results show that, in comparison to wild-type cells, the overexpression of dupα7-Myc in stably-transfected CORM-3 (Figs. 1A and B) did not modify the endogenous expression of α7 mRNA or protein in either of the two NSCLC cell lines tested (Figs. 1A
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br It is common that lung cancer
2020-07-30
It is common that lung cancer patients have metastasis, which leads to treatment failures [4,16,17]. Metastatic lung cancer is characterized by uncontrolled cell growth in tissues of the lung, which can spread beyond the lung into nearby tissues or other parts of the body by the process of metasta
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br Importantly our findings provide evidence that intensi
2020-07-29
Importantly, our findings provide evidence that intensi-fication of treatment is necessary for patients with Gleason 9–10 disease, both because of its worse prognosis and potentially decreased survival benefit from ADT compared with Gleason 8 disease. Gleason 9–10 PCa harbors Gleason pattern 5 dis
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br Correspondence br Acknowledgments br The
2020-07-28
Correspondence Acknowledgments The authors acknowledge the assistance of Chet Closson (Live Microscopy Core, University of Cincinnati). The authors thank Lisa McMillin (Cincinnati Children’s Hospital Medical Center, Pathology Research Core) for her assistance with organoid embedding and proc
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br b e subtypes consistent with previous reports
2020-07-27
b 2e-16) subtypes, consistent with previous reports [42]. Additional immune checkpoint related expression markers (CTLA4, IFNG, ISG15, PDCD1) also significantly correlated with PD-L1 and PD-L2 mRNA across both subtypes (data not shown). Integrated Copy Number Variation Analysis of DNA and RNA T
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br A previous report showed that AMPK
2020-07-26
A previous report showed that AMPK phosphorylates BRAF at Ser729, disrupts the heterodimerization of BRAF with KSR1, and then prevents the paradoxical activation of MEK-ERK signaling (Shen et al., 2013). We thus examined whether AMPK affects the function of NANOG by phosphorylating BRAF. To this e
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br Hollister EB Gao C Versalovic J Compositional and
2020-07-25
[60] Hollister EB, Gao C, Versalovic J. Compositional and functional features of the gastro-intestinal microbiome and their effects on human health. Gastroenterology 2014; 146:1449–58. [61] Scher JU, Sczesnak A, Longman RS, Segata N, Ubeda C, Bielski C, et al. Expansion of intestinal Prevotella